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Editor-In-Chief's Editorial 2022 January Issue 43:1.

Harris, Curtis C.

Carcinogenesis ; 43(1): 1, 2022 02 11.

Article in English | MEDLINE | ID: covidwho-1730651

Subject(s)

COVID-19/immunology , Pandemics/prevention & control , Vaccines, Synthetic/immunology , mRNA Vaccines/immunology , Humans , Publishing

Cytokine Storms in Cancer and COVID-19.

Turnquist, Casmir; Ryan, Bríd M; Horikawa, Izumi; Harris, Brent T; Harris, Curtis C.

Cancer Cell ; 38(5): 598-601, 2020 11 09.

Article in English | MEDLINE | ID: covidwho-972270

ABSTRACT

During the COVID-19 pandemic, research on "cytokine storms" has been reinvigorated in the field of infectious disease, but it also has particular relevance to cancer research. Interleukin-6 (IL-6) has emerged as a key component of the immune response to SARS-CoV-2, such that the repurposing of anti-IL-6 therapeutics for COVID-19 is now a major line of investigation, with several ongoing clinical trials. We lay a framework for understanding the role of IL-6 in the context of cancer research and COVID-19 and suggest how lessons learned from cancer research may impact SARS-CoV-2 research and vice versa.

Subject(s)

Betacoronavirus/immunology , Coronavirus Infections/complications , Cytokines/blood , Inflammation/etiology , Neoplasms/immunology , Pneumonia, Viral/complications , Severity of Illness Index , COVID-19 , Coronavirus Infections/immunology , Coronavirus Infections/virology , Cytokines/immunology , Humans , Inflammation/pathology , Neoplasms/blood , Neoplasms/virology , Pandemics , Pneumonia, Viral/immunology , Pneumonia, Viral/virology , SARS-CoV-2

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